Summary for sequence 'Q9UNQ0'.

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Homologous sequences were used to calculate a multiple sequence alignment visualizing the conservation of individual short linear motifs.
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(An ELM is listed as filtered when all its matching instances have been filtered out.)

 Globular domains/ TM domains and signal peptide detected by the SMART server

 Results of ELM motif search after globular domain filtering, structural filtering and context filtering.

Matches falling inside globular protein domains are excluded from this list unless having an acceptable structural score (if the structural filter (BETA version) is applicable). If the structural filter (BETA version)is applicable it is possible to view these structures with Jmol

  List of excluded ELMs falling inside SMART/PFAM domains and/or scoring poorly with the structural filter (if applicable).

Matches in this list are only likely to be of interest if they are in accessible surface-exposed loops. Motif matches buried in stably folded cores of globular domains are not plausible candidates.
If the structural filter (BETA version) is applicable it is possible to view these structures with Jmol. For more info consult the PDB structure entry used for structure filtering or the SMART or PFAM entries for useful links to solved 3D structures.

Elm Name	Positions	View in Jmol	Elm Description	Cell Compartment	Pattern	PHI-Blast Instance Mapping	Structural Filter Info	Probability
CLV_C14_Caspase3-7	214-218 [A]	-	Caspase-3 and Caspase-7 cleavage site.	cytosol, nucleus	[DSTE][^P][^DEWHFYC]D[GSAN]	-	-	3.094e-03
CLV_NRD_NRD_1	95-97 [A] 190-192 [A]	- -	N-Arg dibasic convertase (NRD/Nardilysin) cleavage site (X-|-R-K or R-|-R-X).	extracellular, Golgi apparatus, cell surface	(.RK)|(RR[^KR])	-	-	7.465e-03
CLV_PCSK_KEX2_1	192-194 [A] 229-231 [A]	- -	Yeast kexin 2 cleavage site (K-R-|-X or R-R-|-X).	extracellular, Golgi apparatus	[KR]R.	-	-	7.973e-03
CLV_PCSK_PC1ET2_1	192-194 [A] 229-231 [A]	- -	NEC1/NEC2 cleavage site (K-R-|-X).	extracellular, Golgi apparatus, Golgi membrane	KR.	-	-	3.903e-03
CLV_PCSK_SKI1_1	147-151 [A] 263-267 [A] 647-651 [A]	- - -	Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X).	endoplasmic reticulum lumen, endoplasmic reticulum, Golgi apparatus, extracellular	[RK].[AILMFV][LTKF].	-	-	6.821e-03
DOC_CYCLIN_RxL_1	449-458 [A] 479-486 [A] 644-655 [A]	- - -	This motif is mainly based on cyclin A binding peptides and may not apply to all cyclins.	nucleus, membrane, cytosol, centriole, Cajal body	(.|([KRH].{0,3}))[^EDWNSG][^D][RK][^D]L.{0,1}[FLMP].{0,3}[EDST]	-	-	4.211e-03
DOC_MAPK_gen_1	160-170 [A] 191-200 [A] 192-200 [A] 229-240 [A] 230-240 [A]	- - - - -	MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue.	nucleus, cytosol	[KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF]	-	-	4.324e-03
DOC_MAPK_MEF2A_6	482-489 [A]	-	A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases.	nucleus, cytosol, Transcription factor complex	[RK].{2,4}[LIVMP].[LIV].[LIVMF]	-	-	2.584e-03
DOC_MAPK_RevD_3	639-653 [A]	-	Reverse (C to N direction) of the classical MAPK docking motif ELM:DOC_MAPK_gen_1 with an often extended linker region of the bipartite motif.	cytosol, nucleus	[LIVMPFA].[LIV].{1,2}[LIVMP].{4,6}[LIV]..[RK][RK]	-	-	1.805e-04
DOC_PP1_RVXF_1	234-241 [A] 261-267 [A] 645-651 [A]	- - -	Protein phosphatase 1 catalytic subunit (PP1c) interacting motif binds targeting proteins that dock to the substrate for dephosphorylation. The motif defined is [RK]{0,1}[VI][^P][FW].	nucleus, protein phosphatase type 1 complex, cytosol	..[RK].{0,1}[VIL][^P][FW].	-	-	8.301e-04
DOC_USP7_MATH_1	392-396 [A] 529-533 [A]	- -	The USP7 MATH domain binding motif variant based on the MDM2 and p53 interactions.	nucleus	[PA][^P][^FYWIL]S[^P]	-	-	1.239e-02
DOC_USP7_UBL2_3	229-233 [A]	-	The USP7 CTD domain binding motif variant based on the ICP0 and DNMT1 interactions	nucleus	K...K	-	-	3.742e-03
LIG_14-3-3_CanoR_1	147-153 [A] 191-200 [A]	- -	Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins.	nucleus, internal side of plasma membrane, cytosol	R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP]))	-	-	4.477e-03
LIG_Actin_RPEL_3	89-108 [A]	-	RPEL motif, present in proteins in several repeats, mediates binding to the hydrophobic cleft created by subdomains 1 and 3 of G-actin.	cytosol	[IL]..[^P][^P][^P][^P]R.....[IL]..[^P][^P][ILV][ILM]	-	-	6.116e-06
LIG_Actin_WH2_2	133-149 [A]	-	The WH2 motif is of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding.	cytosol	[^R]..((.[ILMVF])|([ILMVF].))[^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATIGS]	-	-	6.603e-04
LIG_BRCT_BRCA1_1	204-208 [A] 485-489 [A]	- -	Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity	nucleus, BRCA1-BARD1 complex	.(S)..F	-	-	1.912e-03
LIG_Clathr_ClatBox_1	447-451 [A]	-	Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain.	cytosol, Golgi apparatus, cytoskeleton, clathrin-coated endocytic vesicle, Golgi trans-face	L[IVLMF].[IVLMF][DE]	-	-	3.406e-04
LIG_eIF4E_1	247-253 [A]	-	Motif binding to the dorsal surface of eIF4E.	cytosol	Y....L[VILMF]	-	-	1.891e-04
LIG_FHA_1	131-137 [A] 178-184 [A] 211-217 [A] 400-406 [A] 488-494 [A]	- - - - -	Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position.	nucleus	..(T)..[ILV].	-	-	8.662e-03
LIG_FHA_2	133-139 [A] 151-157 [A] 212-218 [A]	- - -	Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position.	nucleus, Replication fork	..(T)..[DE].	-	-	8.286e-03
LIG_GBD_Chelix_1	633-641 [A]	-	Amphipatic alpha helix that binds the GTPase-binding domain (GBD) in WASP and N-WASP.	extracellular exosome, vesicle membrane, cytosol, actin cytoskeleton, cell-cell junction	[ILV][VA][^P][^P][LI][^P][^P][^P][LM]	-	-	9.792e-05
LIG_LIR_Gen_1	486-492 [A] 642-648 [A]	- -	Canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy.	cytosol, cytoplasmic side of late endosome membrane	[EDST].{0,2}[WFY]..[ILV]	-	-	5.200e-03
LIG_LIR_Nem_3	248-253 [A] 486-492 [A] 642-648 [A]	- - -	Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy.	cytosol, cytoplasmic side of late endosome membrane	[EDST].{0,2}[WFY]..[ILVFY]	-	-	6.362e-03
LIG_Pex14_2	507-511 [A] 547-551 [A]	- -	Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14	cytosol, peroxisome, glycosome	F...[WF]	-	-	4.628e-04
LIG_Rb_pABgroove_1	247-255 [A]	-	The LxxLFD motif binds in a deep groove between pocket A and pocket B of the Retinoblastoma protein	nucleus, Transcription factor complex, Rb-E2F complex	..[LIMV]..[LM][FY]D.	-	-	2.475e-05
LIG_RRM_PRI_1	495-502 [A]	-	The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein.	nucleus, heterogeneous nuclear ribonucleoprotein complex	.[ILVM]LG..P.	-	-	8.391e-05
LIG_SH2_STAT3	123-126 [A]	-	YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain.	cytosol	(Y)..Q	-	-	7.975e-04
LIG_SH2_STAT5	123-126 [A] 413-416 [A] 494-497 [A] 645-648 [A]	- - - -	STAT5 Src Homology 2 (SH2) domain binding motif.	cytosol	(Y)[VLTFIC]..	-	-	3.296e-03
LIG_SUMO_SIM_anti_2	87-94 [A] 88-94 [A] 254-261 [A] 255-261 [A]	- - - -	Motif for the antiparallel beta augmentation mode of non-covalent binding to SUMO protein.	PML body, nucleus, nuclear body	[DEST]{1,10}.{0,1}[VIL][DESTVILMA][VIL][VILM].[DEST]{0,5}	-	-	2.349e-03
LIG_SUMO_SIM_par_1	132-138 [A] 532-538 [A]	- -	Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein.	PML body, nucleus, nuclear body	[DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10}	-	-	4.545e-03
LIG_TRAF2_1	269-272 [A]	-	Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails.	cytosol	[PSAT].[QE]E	-	-	4.300e-03
LIG_TYR_ITIM	492-497 [A] 643-648 [A]	- -	ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase.	cytosol	[ILV].(Y)..[ILV]	-	-	2.992e-04
LIG_UBA3_1	63-72 [A] 89-97 [A] 225-233 [A] 227-233 [A] 496-502 [A] 639-647 [A] 648-653 [A]	- - - - - - -	UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions.	nucleus	[ILM][ILMF].{1,2}[ILM].{0,4}K	-	-	1.196e-03
LIG_WD40_WDR5_VDV_2	87-92 [A] 88-92 [A] 133-136 [A] 143-148 [A] 199-206 [A] 202-206 [A] 203-206 [A] 254-258 [A] 255-258 [A] 440-447 [A] 441-447 [A] 443-447 [A] 532-539 [A] 535-539 [A] 642-648 [A] 645-648 [A]	- - - - - - - - - - - - - - - -	Fungi-specific variant of the WDR5-binding motif that binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes.	nucleus, histone methyltransferase complex	[EDSTY].{0,4}[VIPLA][TSDEKR][ILVA]	-	-	4.678e-02
MOD_CK1_1	100-106 [A] 440-446 [A] 519-525 [A] 532-538 [A] 535-541 [A]	- - - - -	CK1 phosphorylation site	cytosol, nucleus	S..([ST])...	-	-	1.704e-02
MOD_CK2_1	132-138 [A] 150-156 [A] 184-190 [A] 440-446 [A]	- - - -	CK2 phosphorylation site	nucleus, cytosol, protein kinase CK2 complex	...([ST])..E	-	-	1.457e-02
MOD_GlcNHglycan	98-102 [A] 99-102 [A] 102-105 [A] 120-123 [A] 142-145 [A] 186-189 [A] 260-263 [A] 442-445 [A] 518-521 [A] 551-554 [A]	- - - - - - - - - -	Glycosaminoglycan attachment site	extracellular, Golgi apparatus	[ED]{0,3}.(S)[GA].	-	-	1.792e-02
MOD_GSK3_1	173-180 [A] 211-218 [A] 234-241 [A] 254-261 [A] 483-490 [A] 535-542 [A]	- - - - - -	GSK3 phosphorylation recognition site	cytosol, nucleus	...([ST])...[ST]	-	-	2.679e-02
MOD_N-GLC_2	436-438 [A]	-	Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C	extracellular, Golgi apparatus, endoplasmic reticulum	(N)[^P]C	-	-	2.973e-04
MOD_NEK2_1	140-145 [A] 148-153 [A] 216-221 [A] 252-257 [A] 258-263 [A] 431-436 [A] 432-437 [A] 509-514 [A] 539-544 [A] 549-554 [A]	- - - - - - - - - -	NEK2 phosphorylation motif with preferred Phe, Leu or Met in the -3 position to compensate for less favorable residues in the +1 and +2 position.	centrosome, Ndc80 complex, condensed nuclear chromosome outer kinetochore, cytosol, nucleus	[FLM][^P][^P]([ST])[^DEP][^DE]	-	-	9.798e-03
MOD_NEK2_2	132-137 [A] 245-250 [A]	- -	NEK2 phosphorylation motif with specific set of residues in the +1 and +2 position to compensate for less favorable residues in the -3 position.	centrosome, Ndc80 complex, condensed nuclear chromosome outer kinetochore, cytosol, nucleus	[WYPCAG][^P][^P]([ST])[IFCVML][KRHYF]	-	-	1.295e-03
MOD_PIKK_1	177-183 [A]	-	(ST)Q motif which is phosphorylated by PIKK family members.	nucleus, cytosol	...([ST])Q..	-	-	9.230e-03
MOD_PK_1	192-198 [A]	-	Phosphorylase kinase phosphorylation site	cytosol	[RK]..(S)[VI]..	-	-	9.418e-04
MOD_PKA_1	191-197 [A] 192-198 [A] 229-235 [A]	- - -	Main preference for PKA-type AGC kinase phosphorylation.	cAMP-dependent protein kinase complex, cytosol, nucleus	[RK][RK].([ST])[^P]..	-	-	2.315e-03
MOD_PKA_2	192-198 [A] 229-235 [A] 245-251 [A]	- - -	Secondary preference for PKA-type AGC kinase phosphorylation.	cytosol, nucleus, cAMP-dependent protein kinase complex	.R.([ST])[^P]..	-	-	9.458e-03
MOD_Plk_4	85-91 [A] 202-208 [A] 245-251 [A] 254-260 [A] 399-405 [A] 483-489 [A] 529-535 [A] 535-541 [A]	- - - - - - - -	Ser/Thr residue phosphorylated by Plk4	nucleus, cytosol, SCF ubiquitin ligase complex, cleavage furrow, centriole, gamma-tubulin ring complex, centriolar satellite, pericentriolar material	..[^IRFW]([ST])[ILMVFWY][ILMVFWY].	-	-	6.019e-03
MOD_SUMO_rev_2	171-178 [A] 187-194 [A] 446-455 [A]	- - -	Inverted version of SUMOylation motif recognized for modification by SUMO-1	PML body, nucleus	[SDE].{0,5}[DE].(K).{0,1}[AIFLMPSTV]	-	-	1.280e-02
TRG_ENDOCYTIC_2	247-250 [A] 413-416 [A] 494-497 [A] 645-648 [A]	- - - -	Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex	plasma membrane, clathrin-coated endocytic vesicle, cytosol	Y..[LMVIF]	-	-	2.587e-03
TRG_LysEnd_APsAcLL_1	254-259 [A]	-	Sorting and internalisation signal found in the cytoplasmic juxta-membrane region of type I transmembrane proteins. Targets them from the Trans Golgi Network to the lysosomal-endosomal-melanosomal compartments. Interacts with adaptor protein (AP) complexes	cytosol, Endocytic vesicle	[DERQ]...L[LVI]	-	-	2.758e-03
TRG_NES_CRM1_1	159-171 [A] 446-458 [A]	- -	Some proteins re-exported from the nucleus contain a Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein.	nucleus, cytosol	([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ])	-	-	7.626e-04
TRG_Pf-PMV_PEXEL_1	163-167 [A]	-	Plasmodium Export Element, PEXEL, is a trafficking signal for protein cleavage by PMV protease and export from Plasmodium parasites to infected host cells.	endoplasmic reticulum, host cell cytoplasm, extracellular, host cell outer membrane, pathogen-containing vacuole membrane	(R.[LI].[EDQ])|(R.L..[EDQ])|(K.L.E)	-	-	2.161e-03